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Can we improve outcome of congenital diaphragmatic hernia?
L van den Hout1, I Sluiter, S Gischler
1Department of Paediatric Surgery, ErasmusMC-Sophia, Rotterdam, The Netherlands.
Insights
Congenital diaphragmatic hernia (CDH) management requires early recognition and improved treatments to boost survival and prevent long-term issues. Collaborative international efforts are crucial for advancing CDH care and research.
Area of Science:
- Pediatric Surgery
- Neonatology
- Medical Genetics
Background:
- Congenital diaphragmatic hernia (CDH) is a complex birth defect with significant mortality and morbidity.
- Understanding the full disease spectrum, including etiology and long-term outcomes, is essential for optimal patient management.
Purpose of the Study:
- To provide a comprehensive overview of congenital diaphragmatic hernia (CDH).
- To discuss etiological factors, survival predictors, novel treatments, and long-term morbidity associated with CDH.
- To emphasize the need for multidisciplinary care and international collaboration in managing CDH.
Main Methods:
- This review synthesizes current knowledge on CDH through a comprehensive literature search.
- It examines etiological factors, prenatal prognostic indicators, and emerging therapeutic strategies.
- Long-term patient outcomes and morbidity patterns are analyzed.
Main Results:
- Early identification and optimized treatment strategies can improve survival rates and reduce secondary complications in CDH patients.
- Multidisciplinary healthcare approaches are vital for enhancing the quality of care for individuals with CDH.
- The review highlights the need for international cooperation due to the rarity of CDH and the limited evidence for many treatments.
Conclusions:
- Improved recognition and treatment strategies for CDH can lead to better survival and reduced long-term morbidity.
- A multidisciplinary approach and international collaboration, exemplified by the CDH Euro-Consortium, are critical for advancing CDH research and treatment protocols.
Abstract:
This review gives an overview of the disease spectrum of congenital diaphragmatic hernia (CDH). Etiological factors, prenatal predictors of survival, new treatment strategies and long-term morbidity are described. Early recognition of problems and improvement of treatment strategies in CDH patients may increase survival and prevent secondary morbidity. Multidisciplinary healthcare is necessary to improve healthcare for CDH patients. Absence of international therapy guidelines, lack of evidence of many therapeutic modalities and the relative low number of CDH patients calls for cooperation between centers with an expertise in the treatment of CDH patients. The international CDH Euro-Consortium is an example of such a collaborative network, which enhances exchange of knowledge, future research and development of treatment protocols.
