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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
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Allergic Drug Reactions01:27

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
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Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
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Related Experiment Video

Updated: Jun 21, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
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Allergen databases: current status and perspectives.

Adriano Mari1, Chiara Rasi, Paola Palazzo

  • 1Center for Clinical and Experimental Allergology, IDI-IRCCS, Rome, Italy. adriano.mari@allergome.org

Current Allergy and Asthma Reports
|August 13, 2009
PubMed
Summary

This review highlights the challenges in allergen data management due to database heterogeneity. It proposes a unified platform for integrating diverse allergen information, improving allergenicity studies.

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Area of Science:

  • Immunology and Bioinformatics
  • Computational Biology and Allergy Research

Background:

  • Over 1500 allergens are documented, with increasing research.
  • Current allergen databases are heterogeneous, hindering data integration.
  • Interconnectivity is lacking compared to other biomedical fields.

Purpose of the Study:

  • To review the current state of allergen databases and bioinformatics tools.
  • To analyze bioinformatics applications in other medical fields.
  • To propose a unified platform for allergen data integration.

Main Methods:

  • Literature review of allergen databases and bioinformatics tools.
  • Analysis of bioinformatics strategies in related medical domains.
  • Case study using the Allergome platform and its integrated modules.

Main Results:

  • Heterogeneity in allergen databases impedes data sharing and analysis.
  • Bioinformatics offers potential solutions for allergenicity assessment.
  • The Allergome platform demonstrates successful data integration and tool interconnectivity.

Conclusions:

  • A common platform is needed to merge experimental, clinical, and epidemiological allergen data.
  • Integrated data can enhance the study of allergenicity.
  • Standardized approaches are crucial for advancing allergy research through bioinformatics.