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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Updated: Jun 21, 2026

Multiple-mouse Neuroanatomical Magnetic Resonance Imaging

Multiple-mouse Neuroanatomical Magnetic Resonance Imaging

Published on: February 27, 2011

Dedicated low-field MRI in mice.

P Choquet¹, E Breton, C Goetz

¹Laboratoire de Biomécanique, IMFS, Service de Biophysique et Médecine Nucléaire, Hôpitaux Universitaires de Strasbourg, CHU Hautepierre, 1 Avenue Molière, 67098 Strasbourg, France.

Physics in Medicine and Biology

|August 13, 2009

Summary

This summary is machine-generated.

Low-field magnetic resonance imaging (MRI) systems are effective for in vivo mouse imaging. This cost-effective technology is accessible for small research units, enabling detailed rodent studies.

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Area of Science:

Biomedical Imaging
Medical Physics
Small Animal Research

Background:

In vivo magnetic resonance imaging (MRI) is crucial for preclinical research.
Dedicated low-field MRI systems offer potential advantages in cost and accessibility.

Purpose of the Study:

To demonstrate the relevance and utility of low-field MRI for in vivo mouse imaging.
To assess the feasibility of using a dedicated 0.1 T system for rodent studies.

Main Methods:

Utilized a 0.1 T water-cooled electromagnet and solenoidal radio frequency (RF) coils.
Acquired all images in three-dimensional (3D) mode with an optimized isolation cell for anesthesia and warming.
Acquired images with and without contrast agents in normal mice and tumor-bearing models.

Main Results:

Achieved typical in-plane pixel dimensions from 200 x 200 to 500 x 500 micrometers.
Slice thicknesses ranged from 0.65 to 1.50 mm.
Total acquisition times varied from 30 minutes to 4 hours.

Conclusions:

Dedicated low-field MRI systems are suitable for small rodent imaging.
These systems are cost-effective, easy to install, and accessible for smaller research facilities.
Low-field MRI expands imaging capabilities for diverse preclinical research applications.