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Illusionary self-motion perception in zebrafish.

Ying-Yu Huang1, Markus Tschopp, Stephan C F Neuhauss

  • 1Department of Biology, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland.

Plos One
|August 13, 2009
PubMed
Summary
This summary is machine-generated.

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Zebrafish mutants with defective optic chiasm formation exhibit a novel looping swimming behavior. This looping is linked to visual input and eye movement, suggesting a role for visual-afferent and efference copy signals in postural control.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Behavioral Biology

Background:

  • The zebrafish belladonna (bel) mutant has a mutation in the lhx2 gene, causing defects in retinotectal axon pathfinding and optic chiasm formation.
  • Achiasmatic bel mutants exhibit oculomotor instabilities: reversed optokinetic response (OKR) and congenital nystagmus (CN).

Purpose of the Study:

  • To investigate a novel swimming behavior, termed looping, in bel mutants.
  • To explore the relationship between looping, oculomotor instabilities, and visual input in postural control.

Main Methods:

  • Observation of swimming behavior in bel mutants and wild-type zebrafish.
  • Correlation analysis of looping with reversed OKR and CN.
  • Assessment of vision-dependence and contrast sensitivity of looping.

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  • Evoking looping behavior in wild-type fish using whole-field motion.

    • Main Results:

    • Bel mutants display a novel looping swimming behavior that perfectly correlates with reversed OKR and CN.
    • Looping is vision-dependent and contrast-sensitive.
    • Congenital nystagmus precedes looping, and its slow phase direction predicts looping direction.
    • Looping can be evoked in wild-type fish by whole-field motion, indicating self-motion perception.

    Conclusions:

    • Looping behavior in bel mutants is likely triggered by congenital nystagmus and represents a form of self-motion perception.
    • Postural control in vertebrates relies on both direct visual input (afference) and eye-movement-related signals (efference copy/reafference).