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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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Published on: February 13, 2016

A monolithic polymeric microdevice for pH-responsive drug delivery.

Jian Chen1, Michael Chu, Khajag Koulajian

  • 1Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G8, Canada.

Biomedical Microdevices
|August 13, 2009
PubMed
Summary
This summary is machine-generated.

This study introduces a novel drug-delivery microdevice with intelligent nano-valves. The device demonstrates controlled drug release in response to pH changes, offering a new platform for targeted therapies.

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Developing controlled drug delivery systems is crucial for effective therapeutics.
  • Existing systems often require external components or complex mechanisms for rate control.
  • Intelligent materials that respond to physiological cues offer a promising avenue for advanced drug delivery.

Purpose of the Study:

  • To design and fabricate a monolithic drug-delivery microdevice.
  • To integrate pH-responsive nano-hydrogel particles as intelligent nano-valves.
  • To demonstrate controlled drug release based on local pH variations.

Main Methods:

  • Synthesis of pH-responsive nanoparticles.
  • Embedding nanoparticles into a composite membrane.
  • Integration of composite membranes with polydimethylsiloxane (PDMS) micro-reservoirs using room-temperature transfer bonding.
  • In vitro drug release studies using Vitamin B12 (VB12) as a model drug at different pH levels (7.4 and 4).

Main Results:

  • The microdevices functioned monolithically without external control hardware.
  • A significant increase in drug release rate was observed when the pH decreased from 7.4 to 4.
  • The pH-responsive nano-hydrogel particles effectively acted as intelligent nano-valves.

Conclusions:

  • The developed microdevice successfully demonstrates controlled, pH-responsive drug release.
  • This platform technology holds potential for intelligent drug delivery systems that respond to in vivo environmental signals.
  • The monolithic design simplifies the system and reduces the need for additional components.