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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
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Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Centrally Acting Muscle Relaxants: Therapeutic Uses01:24

Centrally Acting Muscle Relaxants: Therapeutic Uses

Centrally acting muscle relaxants reduce muscle tone and tension by interfering with the postsynaptic reflexes in the central nervous system.
Centrally acting drugs are classified into spasmolytic and antispasmodic drugs. Spasmolytic drugs such as baclofen, diazepam, and tizanidine inhibit spinal motor neurons and decrease muscle tone. Spasmolytic drugs are administered for severe and chronic spasms due to multiple sclerosis, cerebral palsy, stroke, and spinal cord and muscle injuries. However,...
Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

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A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers
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[Chronic pain therapy].

U W Buettner1

  • 1Neurologische Klinik, Kantonsspital Aarau, Tellstrasse, Aarau. buettner@ksa.ch

Praxis
|August 13, 2009
PubMed
Summary
This summary is machine-generated.

Chronic pain is a significant health issue with socio-economic impacts. Effective management requires a multidisciplinary approach, moving beyond solely drug-oriented treatments.

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Area of Science:

  • Pain research
  • Neuroscience
  • Public health

Context:

  • Chronic pain presents a substantial health burden in developed nations, impacting individuals and healthcare systems.
  • Understanding the fundamental mechanisms of chronic pain development is crucial for therapeutic advancements.
  • Current drug-oriented treatments for chronic pain require enhancement.

Purpose:

  • To explore mechanism-oriented therapeutic strategies for chronic pain.
  • To advocate for an improved, comprehensive approach to chronic pain management.
  • To emphasize the role of interdisciplinary care in managing complex chronic pain states.

Summary:

  • The development of chronic pain, while partially understood, allows for mechanism-targeted therapies.
  • Current drug-focused pain management strategies need improvement.
  • Complex chronic pain necessitates an interdisciplinary approach involving medical and paramedical professionals.

Impact:

  • Highlights the need for improved pharmacological and non-pharmacological interventions for chronic pain.
  • Stresses the importance of integrating various medical and paramedical disciplines for optimal patient outcomes.
  • Positions semi-invasive and invasive pain therapies as last-resort options, promoting conservative management first.