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Updated: Jun 21, 2026

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells
Published on: October 10, 2017
No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer
Lynette S Phillips1, Cheryl L Thompson, Alona Merkulova
1Department of Epidemiology and Biostatistics and Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106-7136, United States.
Aim:
To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer.
Methods:
We utilized a population-based case-control study of incident colon cancer individuals (n = 421) and controls (n = 483) aged > or = 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene.
Results:
None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer.
Conclusion:
Our study does not support PTEN as a colon cancer susceptibility gene.
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Single Nucleotide Polymorphisms-SNPs
