Related Experiment Video
Updated: Jun 21, 2026

07:49
Spontaneous Formation and Rearrangement of Artificial Lipid Nanotube Networks as a Bottom-Up Model for Endoplasmic Reticulum
Published on: January 22, 2019
Spontaneous free-boundary structure in crumpled membranes
1James Franck Institute, University of Chicago, Chicago, Illinois 60637, USA.
The Journal of Physical Chemistry. B
|August 13, 2009
Summary
High boundary curvature in crumpled elastic membranes lowers interior ridge energy. This creates sharp edges, with edge energy growing with membrane size, impacting membrane structure and stability.
Area of Science:
- Physics
- Materials Science
- Applied Mathematics
Background:
- Crumpled elastic membranes exhibit complex structures dominated by singularities.
- Stretching-ridge singularities are key to understanding the behavior of highly deformed elastic membranes.
Purpose of the Study:
- To investigate the strong boundary curvature in thin crumpled elastic membranes.
- To analyze the role of stretching-ridge singularities in membrane deformation.
- To understand how boundary curvature affects interior ridge energy and membrane structure.
Main Methods:
- Experimental setup using a membrane fastened into a bag shape with a single stretching ridge.
- Theoretical analysis of high-curvature regions and their energy contributions.
- Mathematical modeling of edges as conical sectors and analysis of edge energy scaling.
Main Results:
- High boundary curvature points reduce the energy of the interior stretching ridge.
- In the limit of small thickness, arbitrarily strong induced curvature forms sharp edges.
- Edge energy scales with the square root of the central ridge energy as membrane size increases.
Conclusions:
- Boundary curvature is a critical factor in the mechanics of crumpled elastic membranes.
- The formation of sharp edges significantly influences the energy landscape and structural stability.
- Understanding these phenomena is crucial for predicting the behavior of thin, deformed materials.
Related Concept Videos
Mechanisms of Membrane-bending
The living membranes are flexible due to their fluid mosaic nature; however, their bending into different shapes is an active process regulated by specific lipids and proteins. The membrane bending can be transient as seen in vesicles or stable for a long time as in microvilli. Cells regulate the size, location, and duration of the membrane curvature.
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
Mechanisms of Membrane Domain Formation
Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with cytoskeletal...
Another mechanism for membrane domain formation involves membrane proteins interacting with cytoskeletal...
Fluid Mosaic Model
Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich with the analogy of...
Membrane Fluidity
Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
Membrane Fluidity
Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.Fatty acids tails of phospholipids can be either saturated or...
Membrane Asymmetry Regulating Transporters
Enzymes like flippase, floppase, and scramblase transfer phospholipids from one layer to another in the membrane, thereby affecting membrane asymmetry.
Flippase
Eukaryotic flippases are type-IV P-type ATPases or P4-ATPases belonging to P-type ATPase family proteins that are membrane-bound pumps involved in the ATP-mediated transport of ions and molecules across the membrane. Flippases flip specific phospholipids from the outer to the inner leaflet of a membrane. All P4-ATPases have one...
Flippase
Eukaryotic flippases are type-IV P-type ATPases or P4-ATPases belonging to P-type ATPase family proteins that are membrane-bound pumps involved in the ATP-mediated transport of ions and molecules across the membrane. Flippases flip specific phospholipids from the outer to the inner leaflet of a membrane. All P4-ATPases have one...

