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Related Concept Videos

Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Fibrous Proteins00:55

Fibrous Proteins

Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...
Types of Skeletal Muscle Fibers01:32

Types of Skeletal Muscle Fibers

Skeletal muscles comprise various fibers, each with distinct characteristics and roles in movement and stability. They are mainly categorized into three types — fast-twitch, slow-twitch, and intermediate.
Fast-twitch fibers
Fast-twitch fibers, or Type II fibers, are designed for quick, powerful bursts of speed and strength. They reach peak tension within approximately 0.01 seconds following stimulation. Characterized by a large diameter and densely packed myofibrils, these fibers contain...
Classification of Skeletal Muscle Fibers01:48

Classification of Skeletal Muscle Fibers

Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
Fascicle Arrangement in Skeletal Muscles01:25

Fascicle Arrangement in Skeletal Muscles

Fascicles are bundles of muscle fibers in a skeletal muscle. Muscle fascicle arrangement is directly associated with the power and range of motion of various muscles. The configuration of these fascicles can vary, leading to different functional outcomes.
The four primary types of muscle based on fascicle arrangement are:

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Related Experiment Video

Updated: Jun 21, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Elastic fiber pattern in scleroderma/morphea.

Ruth Walters1, Melissa Pulitzer, Hideko Kamino

  • 1Dermatopathology Section, Department of Dermatology, New York University Medical Center, New York, NY 10016, USA. ruth.walters@nyumc.org

Journal of Cutaneous Pathology
|August 14, 2009
PubMed
Summary

Scleroderma/morphea shows preserved, parallel, and compressed elastic fibers, often correlating with sclerosis. This elastic fiber pattern, along with CD34 staining, aids diagnosis.

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Dissection of Single Skeletal Muscle Fibers for Immunofluorescent and Morphometric Analyses of Whole-Mount Neuromuscular Junctions
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Dissection of Single Skeletal Muscle Fibers for Immunofluorescent and Morphometric Analyses of Whole-Mount Neuromuscular Junctions

Published on: August 14, 2021

Fiber Type Identification of Human Skeletal Muscle
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Fiber Type Identification of Human Skeletal Muscle

Published on: September 22, 2023

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Dissection of Single Skeletal Muscle Fibers for Immunofluorescent and Morphometric Analyses of Whole-Mount Neuromuscular Junctions
08:41

Dissection of Single Skeletal Muscle Fibers for Immunofluorescent and Morphometric Analyses of Whole-Mount Neuromuscular Junctions

Published on: August 14, 2021

Fiber Type Identification of Human Skeletal Muscle
07:04

Fiber Type Identification of Human Skeletal Muscle

Published on: September 22, 2023

Area of Science:

  • Dermatopathology
  • Connective tissue diseases

Background:

  • Scleroderma/morphea involves dermal thickening and loss of CD34(+) cells.
  • Elastic fiber changes are variable and poorly studied in relation to CD34 expression.

Purpose of the Study:

  • To systematically analyze elastic fiber patterns in scleroderma/morphea.
  • To correlate elastic fiber morphology with CD34 expression and disease stage.

Main Methods:

  • Examined 7 normal skin and 28 scleroderma/morphea biopsies.
  • Performed CD34 immunohistochemistry on 26 biopsies.
  • Utilized Elastic van Gieson staining for elastic fibers.

Main Results:

  • Elastic fibers were preserved in all cases.
  • Parallel, straightened, and compressed elastic fibers were frequent (limited in 46%, diffuse in 54%).
  • Elastic fiber alteration correlated with sclerosis; CD34(+) cells were variably lost.

Conclusions:

  • Elastic fibers are frequently parallel, straightened, and compressed in scleroderma/morphea.
  • The elastic fiber pattern is a useful diagnostic adjunct alongside CD34 immunohistochemistry.