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Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
Published on: July 19, 2018
[Evaluating renal function and indications for starting dialysis]
José Luis Teruel1, Jaime Torrente, Milagros Fernández Lucas
1Servicio de Nefrología, Hospital Ramón y Cajal, Madrid. jteruel.hrc@salud.madrid.org
Insights
Kidney transplant recipients require continuous monitoring of renal function using glomerular filtration rate (GFR) calculations. Early dialysis initiation, when GFR falls below 15 ml/min/1.73 m2, prevents complications and ensures timely vascular access.
Area of Science:
- Nephrology
- Transplant Medicine
- Renal Function Evaluation
Context:
- Post-kidney transplant graft function monitoring is crucial.
- Patients with chronic graft dysfunction often initiate dialysis late, leading to uremic complications.
- Programmed dialysis initiation is preferred over emergency initiation in transplant recipients.
Purpose:
- To outline optimal strategies for monitoring renal function in transplant recipients.
- To define criteria for initiating dialysis in patients with chronic graft dysfunction.
- To emphasize the importance of programmed dialysis initiation and timely vascular access creation.
Summary:
- Glomerular filtration rate (GFR) estimation using serum creatinine, particularly the MDRD formula, is essential for graft function follow-up.
- All transplanted patients should be classified under Chronic Kidney Disease (CKD) staging, with interventions applied from stage 1-3.
- Dialysis should be considered when GFR is <15 ml/min/1.73 m2 or when uremic complications arise.
- Programmed dialysis initiation requires prompt vascular surgery evaluation for access, ideally when GFR <20 ml/min/1.73 m2.
- Peritoneal dialysis requires catheter placement at least 15 days before training initiation.
Impact:
- Improved management of kidney transplant recipients.
- Reduced incidence of uremic complications in post-transplant patients requiring dialysis.
- Enhanced planning and execution of dialysis initiation, leading to better patient outcomes.
- Standardized protocols for renal function monitoring and dialysis initiation in transplant care.
Abstract:
EVALUATION OF THE RENAL FUNCTION: For the follow-up of the graft renal function it must be measured the glomerular filtration rate by means of formulae that use the serum creatinine. The most used equation is the brief formula MDRD. - All patients transplanted must be included in the group of Renal Chronic Disease though the glomerular filtration rate is normal and there is no evidence of renal damage. - The measures of intervention proposed in the classification of the Renal Chronic Disease for its progressive establishment in the stage 1 to 3, must be applied to all the transplanted THE BEGINNING OF DIALYSIS: In spite of receiving attention of Nephrologists along the whole evolution, the patients with chronic dysfunction of the graft that need treatment with dialysis start later and with more uremic complications that the patients who start dialysis for the first time. - To change this trend, it is necessary to consider the treatment with dialysis when the glomerular filtration rate is lower than 15 ml/min/1,73 m2. If there appears any complication related to the uremia that cannot be handled by conservative treatment, the beginning of the dialysis is necessary. THE BEGINNING OF THE DIALYSIS OF PROGRAMMED FORM: The beginning of the dialysis of not programmed form in transplanted patients is difficult to justify if we take into account that such patients, have received nephrological attention along all their evolution. - To get a new vascular access in these patients can be difficult depending on the previous trombosis of arteriovenous fistulas. Therefore, it must be realized a prompt evaluation for de department of vascular surgery to guarantee a suitable vascular access. - As general norm, one must follow the same criterion advised for the not transplanted patient: the vascular access must be considered when the glomerular filtration rate is lower than 20 m/min/1,73 m2. - The patient who is going to be treated by dialysis peritoneal precise a very narrow follow-up to be able to programme the placement of the catheter peritoneal with a minimum of 15 days before beginning the training.
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