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Updated: Jun 21, 2026
08:58
Murine Kidney Transplant Technique
Published on: October 20, 2015
[Managing a failed kidney graft. Nephrectomy versus embolisation].
Isabel Pérez-Flores1, Ana Sánchez-Fructuoso, Roberto Marcén
1Servicio de Nefrología, Hospital Clínico San Carlos, Madrid.
Summary
Early diagnosis of kidney transplant intolerance is crucial. Less invasive embolization is preferred over transplantectomy for managing chronic inflammation, reducing infection risks.
Area of Science:
- Nephrology
- Transplant Surgery
- Immunology
Background:
- Early diagnosis of graft intolerance syndrome or subclinical chronic inflammation in kidney allografts is a key nephrologist goal.
- Clinical signs include fever, hematuria, and local pain, but subclinical cases present with inflammation markers like elevated C-reactive protein and resistant anemia.
Purpose of the Study:
- To outline diagnostic and management strategies for kidney allograft intolerance.
- To evaluate treatment options, favoring less invasive procedures.
Main Methods:
- Review of clinical criteria for diagnosis.
- Assessment of inflammatory markers.
- Evaluation of treatment options including immunosuppression, transplantectomy, and embolization.
Main Results:
- Subclinical inflammation is often indicated by elevated inflammatory markers.
- Immunosuppression is not recommended due to infection and cardiovascular risks.
- Embolization is a less invasive alternative to transplantectomy for managing allograft intolerance, especially when complications are absent.
Conclusions:
- Early detection of kidney allograft intolerance is vital.
- Embolization offers a less invasive approach compared to transplantectomy.
- Prophylactic antibiotics are recommended before embolization to prevent infectious complications.
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