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Platelet-derived growth factor-BB reflects clinical, inflammatory and angiogenic disease activity and oxidative
Malgorzata Krzystek-Korpacka1, Katarzyna Neubauer, Malgorzata Matusiewicz
1Department of Medical Biochemistry, Wroclaw Medical University, ul. Chalubinskiego 10, Wroclaw, Poland. krzystek@bioch.am.wroc.pl
Insights
Platelet-derived growth factor (PDGF) increases in active inflammatory bowel disease (IBD), correlating with disease activity. However, PDGF is not a superior marker compared to existing inflammatory markers for IBD.
Area of Science:
- Gastroenterology
- Immunology
- Biochemistry
Background:
- Inflammatory bowel disease (IBD) encompasses chronic inflammatory conditions of the gastrointestinal tract.
- Platelet-derived growth factor (PDGF) plays roles in cell growth, proliferation, and inflammation.
- Understanding PDGF's role in IBD pathogenesis and its potential as a biomarker is crucial.
Purpose of the Study:
- To evaluate serum and plasma levels of platelet-derived growth factor (PDGF)-BB in patients with inflammatory bowel disease (IBD).
- To assess the correlation of PDGF-BB levels with IBD disease status, activity, and associated biological processes.
- To determine the diagnostic utility of PDGF-BB as a potential biomarker for active IBD.
Main Methods:
- Measurement of serum and plasma PDGF-BB in 134 IBD patients and 81 controls.
- Evaluation of PDGF-BB levels against disease activity, endoscopic findings, inflammation, and angiogenesis.
- Receiver Operating Characteristic (ROC) analysis to assess diagnostic utility.
Main Results:
- PDGF-BB levels were elevated in active IBD, irrespective of disease type, and correlated with clinical and endoscopic activity.
- Serum and plasma PDGF-BB levels showed poor correlation; plasma-PDGF reflected oxidative stress, while serum-PDGF indicated inflammation and angiogenesis.
- Platelets accounted for approximately 30% of PDGF variability, suggesting a mediating role in observed relationships.
Conclusions:
- Increased platelet-stored and circulating PDGF in IBD correlate with disease activity, inflammation, angiogenesis, and oxidative stress.
- PDGF did not demonstrate superior diagnostic performance for active IBD compared to established markers like C-reactive protein, erythrocyte sedimentation rate, and platelet count.
Objectives:
The goal of the studies was the evaluation of platelet-stored (serum) and circulating (plasma) pools of platelet-derived growth factor (PDGF)-BB in inflammatory bowel disease (IBD) and the assessment of a possible application of PDGF as the disease marker.
Design And Methods:
Serum and plasma PDGF-BB were measured in 134 IBD patients and 81 controls and evaluated with respect to the disease status, endoscopic, inflammatory, and angiogenic activity. The diagnostic utility was evaluated using ROC analysis.
Results:
PDGF was increased exclusively in active IBD regardless the disease type and associated with its clinical and endoscopic activity. Serum- and plasma-PDGF were poorly interrelated. Plasma-PDGF better reflected oxidative stress whereas serum-PDGF reflected inflammation and angiogenesis. In multivariate analysis, platelets alone explained about 30% in the PDGF variability and seemed to mediate most of the observed relationships.
Conclusions:
IBD is associated with the increases in platelet-stored and circulating PDGF, which correspond with the disease clinical, endoscopic, inflammatory, and angiogenic activity and IBD-associated oxidative stress. However, PDGF as an active-IBD marker was not better than currently applied C-reactive protein, erythrocyte sedimentation rate and platelets.
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