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[Congenital heart defects in Icelandic twins.]
Laeknabladid
|August 15, 2009
Summary
Congenital heart defects (CHD) are significantly more common in twins (3.21%) than singletons (1.0%). This study found a higher incidence and mortality rate of CHD in twins, particularly in later years.
Area of Science:
- Cardiovascular Medicine
- Pediatrics
- Genetics
Context:
- Congenital heart defects (CHD) affect 0.8-1.1% of newborns.
- Previous studies suggest a higher CHD incidence in twins compared to singletons.
- Icelandic twin births from 1986-1995 provide a unique population for study.
Purpose:
- To determine the incidence and types of CHD in Icelandic twins.
- To compare CHD rates in twins versus the general singleton population in Iceland.
- To analyze trends in CHD incidence during the study period.
Summary:
- A 10-year study in Iceland found CHD incidence in twins to be 3.21%, significantly higher than the 1.0% in singletons.
- Ventricular septal defects were the most common type (40%), followed by atrial septal defects (20%).
- Mortality due to CHD was significantly higher in twins (17%) compared to singletons.
Impact:
- Highlights increased CHD risk in the twin population.
- Suggests a potential link between assisted reproductive technologies (introduced in 1991) and rising CHD incidence in twins.
- Underscores the need for further research into the causes and management of CHD in twins.
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