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Choroid plexus carcinoma: report of two cases
Avninder Singh1, Sarvjot Vermani, Sharma Shruti
1Institute of Pathology-ICMR, New Delhi, India. dravninder@yahoo.co.in
Insights
Choroid plexus carcinomas (CPCs) are rare pediatric brain tumors. This report details two pediatric CPC cases, discussing their clinicopathologic features and poor prognosis.
Area of Science:
- Neuro-oncology
- Pediatric Pathology
- Neurosurgery
Background:
- Choroid plexus carcinomas (CPCs) are rare, aggressive brain tumors in children.
- They arise from the choroid plexus epithelium, typically in the posterior fossa.
- CPCs are malignant counterparts of choroid plexus papillomas and carry a poor prognosis.
Observation:
- This study presents two pediatric cases of choroid plexus carcinoma.
- The patients were a 5-year-old boy and a 12-year-old boy.
- Both cases involved tumors with predilection for the posterior fossa.
Findings:
- Detailed clinicopathologic features of the two CPC cases are discussed.
- The findings highlight the diagnostic challenges and aggressive nature of pediatric CPCs.
- Analysis of these cases contributes to understanding CPC variations.
Implications:
- Improved understanding of CPCs can aid in earlier diagnosis and treatment planning.
- Further research into CPC pathogenesis may reveal novel therapeutic targets.
- These case reports emphasize the need for specialized pediatric neuro-oncology care.
Abstract:
Choroid plexus carcinomas (CPCs) are rare malignant counterparts of choroid plexus papilloma which occur in infants and children with a predilection for the posterior fossa and have a poor prognosis. We report two cases of CPC diagnosed in a 5-year-old boy and a 12-year-old boy and discuss the clinicopathologic features.
