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Will the evolution of overactive bladder delivery systems increase patient compliance?
1New York University Langone Medical Center New York, NY.
Reviews in Urology
|August 15, 2009
Summary
Overactive bladder (OAB) pharmacotherapy faces challenges with oral antimuscarinic side effects limiting patient compliance. This review examines OAB drug delivery systems, focusing on balancing efficacy and tolerability for better treatment outcomes.
Area of Science:
- Pharmacology
- Urology
Background:
- Overactive bladder (OAB) significantly impacts daily quality of life, necessitating effective pharmacotherapy.
- Current treatments primarily target muscarinic receptors (M2 and M3) in the detrusor muscle to control bladder contractions.
Purpose of the Study:
- To review current pharmacologic delivery systems for OAB treatment.
- To analyze patient compliance and reasons for medication discontinuation.
Main Methods:
- Review of existing literature on OAB pharmacotherapy.
- Analysis of drug delivery systems, focusing on efficacy and tolerability.
Main Results:
- Oral antimuscarinic agents commonly cause bothersome side effects due to off-target effects and metabolism.
- These adverse effects often limit tolerability, impacting long-term patient compliance and satisfaction.
Conclusions:
- The therapeutic index (efficacy vs. tolerability) is crucial for successful OAB pharmacotherapy.
- Optimizing drug delivery systems is essential to improve patient compliance and treatment outcomes for overactive bladder.
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