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Antibody to CCDC104 is associated with a paraneoplastic antibody to CDR2 (anti-Yo)
Cecilie Totland1, Geir Bredholt, Mette Haugen
1Department of Neurology, Haukeland University Hospital, Bergen, Norway. cecilie.totland@helse-bergen.no
Abstract:
Patients with cancer may develop paraneoplastic neurological syndromes (PNS) in which onconeural antibodies are important diagnostic findings. As the functional role of onconeural antibodies is largely unknown, insight gained by identifying associated antibodies may help to clarify the pathogenesis of the PNS. In this study, we identified patients with Yo antibodies who also had antibodies to an uncharacterized protein called coiled-coil domain-containing protein 104 (CCDC104). We found a significant association between CCDC104 and Yo antibodies (4 of 38, 10.5%), but not other onconeural antibodies (0 of 158) (P = 0.007, Fisher's exact test). The prevalence of CCDC104 antibodies was approximately similar in patients with cancer (8 of 756, 1.1%) and in healthy blood donors (2 of 300, 0.7%). CCDC104 antibodies were not associated with PNS, as this was found in only two of the ten CCDC104-positive patients. The CCDC104 protein, whose function is unknown, is expressed in various human tissues, including the brain, and is localized mainly to the nucleus, but is also found in the cytoplasm. The association between Yo and CCDC104 antibodies may indicate functional similarities.
Insights
Researchers found a significant association between Yo antibodies and antibodies to coiled-coil domain-containing protein 104 (CCDC104) in cancer patients. This discovery may shed light on the pathogenesis of paraneoplastic neurological syndromes (PNS).
Area of Science:
- Neuroimmunology
- Oncology
- Molecular Biology
Background:
- Paraneoplastic neurological syndromes (PNS) are associated with cancer and characterized by onconeural antibodies.
- The functional roles of most onconeural antibodies remain largely unknown, hindering understanding of PNS pathogenesis.
Purpose of the Study:
- To investigate potential associations between Yo antibodies and antibodies to uncharacterized proteins.
- To identify novel onconeural antibodies and explore their relationship with PNS.
Main Methods:
- Patient serum samples were screened for antibodies against coiled-coil domain-containing protein 104 (CCDC104).
- Statistical analysis, including Fisher's exact test, was used to determine the significance of antibody associations.
- Prevalence of CCDC104 antibodies was assessed in cancer patients and healthy blood donors.
Main Results:
- A significant association was found between Yo antibodies and CCDC104 antibodies (10.5% prevalence).
- No association was observed between CCDC104 antibodies and other onconeural antibodies.
- The prevalence of CCDC104 antibodies was similar in cancer patients (1.1%) and healthy donors (0.7%).
- CCDC104 antibodies were not significantly associated with PNS.
Conclusions:
- The association between Yo and CCDC104 antibodies suggests potential functional similarities.
- Further research into CCDC104 may provide insights into the pathogenesis of Yo antibody-associated PNS.
