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Tooth whitening clinical trials: a global perspective
1The Procter & Gamble Company, Mason, OH 45040-8006, USA. gerlach.rw@pg.com
American Journal of Dentistry
|August 18, 2009
Summary
Hydrogen peroxide whitening strips effectively improve tooth color. Extensive clinical trials confirm their long-term safety and efficacy for dental esthetics.
Area of Science:
- Dentistry
- Cosmetic Dentistry
- Dental Materials Science
Background:
- Tooth whitening has seen significant research since 2000.
- Digital image analysis enhances the reproducibility of color change assessment.
- Product development for whitening strips is ongoing.
Purpose of the Study:
- To evaluate the safety and effectiveness of 6-6.5% hydrogen peroxide whitening strips.
- To assess tooth color improvement using standardized clinical trials.
- To provide evidence for the long-term use of whitening strips.
Main Methods:
- Conducted global randomized controlled trials across diverse sites and cultures.
- Utilized 6-6.5% hydrogen peroxide whitening strips over 7-21 days.
- Performed assessments at research hospitals, dental schools, and private practices.
Main Results:
- Demonstrated significant tooth color improvement compared to baseline and controls.
- Confirmed the absence of serious adverse events during the trials.
- Validated the effectiveness of whitening strips in various populations.
Conclusions:
- Integrated clinical trials provide robust evidence for whitening strip effectiveness.
- 6-6.5% hydrogen peroxide whitening strips are safe for long-term use.
- Digital image analysis supports reproducible assessment of whitening efficacy.
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