Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Cells and Tissue01:30

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhancing abdominal wall healing using an oriented polycaprolactone microfibrous scaffold prepared using the fiber drawing method: A rabbit model study.

Hernia : the journal of hernias and abdominal wall surgery·2026
Same author

Mechanisms Controlling the Behavior of Vascular Smooth Muscle Cells in Hypoxic Pulmonary Hypertension.

Physiological research·2024
Same author

Vascular Damage and Repair - Are Small-Diameter Vascular Grafts Still the "Holy Grail" of Tissue Engineering?

Physiological research·2024
Same author

Effect of diamond-like carbon doped with chromium on cell differentiation, immune activation and apoptosis.

European cells & materials·2020
Same author

Cell type specific adhesion to surfaces functionalised by amine plasma polymers.

Scientific reports·2020
Same author

Modification of human pericardium by chemical crosslinking.

Physiological research·2019

Related Experiment Video

Updated: Jun 21, 2026

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

Osteogenic cells on bio-inspired materials for bone tissue engineering.

B Vagaská1, L Bacáková, E Filová

  • 1Department of Growth and Differentiation of Cell Populations, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

Physiological Research
|August 18, 2009
PubMed
Summary

This review explores advanced artificial bone substitutes, focusing on multi-phase composites that mimic natural bone. Enhancing material surface properties and incorporating bioactive components are key for better integration and tissue regeneration.

More Related Videos

Decellularized Apple-Derived Scaffolds for Bone Tissue Engineering In Vitro and In Vivo
09:49

Decellularized Apple-Derived Scaffolds for Bone Tissue Engineering In Vitro and In Vivo

Published on: February 23, 2024

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Related Experiment Videos

Last Updated: Jun 21, 2026

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

Decellularized Apple-Derived Scaffolds for Bone Tissue Engineering In Vitro and In Vivo
09:49

Decellularized Apple-Derived Scaffolds for Bone Tissue Engineering In Vitro and In Vivo

Published on: February 23, 2024

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Orthopedic Research

Background:

  • Traditional bone substitutes are often single-phase materials.
  • Natural bone is a complex multi-phase composite with intricate architecture.
  • Next-generation bone implants require bioactivity for tissue integration and self-healing.

Purpose of the Study:

  • To review the evolution of artificial bone substitutes.
  • To discuss strategies for enhancing biomaterial biocompatibility and bioactivity.
  • To highlight novel multi-phase composite materials for bone regeneration.

Main Methods:

  • Review of cell-material interaction principles.
  • Analysis of surface modification strategies for biomaterials (chemistry, wettability, charge, rigidity, roughness).
  • Examination of advanced composite materials, including polymer-based options with bioactive components.

Main Results:

  • Nanoroughness on material surfaces preferentially stimulates osteoblast growth over fibroblasts.
  • Multi-phase composites, particularly polymer-based ones, show promise for bone substitution.
  • Incorporation of hydroxyapatite, calcium phosphates, cell adhesion ligands, or growth factors enhances bioactivity.

Conclusions:

  • Optimizing surface properties, especially nanoroughness, is crucial for directing cellular response and improving implant integration.
  • Novel multi-phase composites offer superior mimicry of natural bone structure and function.
  • Bioactive and degradable materials hold significant potential for promoting bone regeneration and replacement.