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Enhancing abdominal wall healing using an oriented polycaprolactone microfibrous scaffold prepared using the fiber

Michala Klusáček Rampichová1,2, Kateřina Strnadová3,4, M Plencner5

  • 1Department of Tissue Engineering, Institute of Experimental Medicine, The Czech Academy of Sciences, Prague, Czech Republic. michala.rampichova@iem.cas.cz.

Hernia : the Journal of Hernias and Abdominal Wall Surgery
|January 16, 2026
PubMed
Summary

A novel biodegradable scaffold made of aligned poly(ε-caprolactone) (PCL) microfibers enhanced abdominal wall repair in rabbits. This PCL scaffold improved tissue strength and healing, showing promise for reducing incisional hernia recurrence.

Keywords:
Abdominal wallFiber drawing methodManufacturing processesRabbitsSurgical wound healingTissue scaffolds

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Incisional hernias are common after abdominal surgery, with high recurrence rates even with synthetic meshes.
  • Developing improved methods for abdominal wall repair is crucial to reduce complications.

Purpose of the Study:

  • To develop and assess a biodegradable, aligned microfibrous scaffold for enhanced abdominal wall repair.
  • To evaluate the scaffold's potential in supporting wound healing and strengthening the abdominal wall.

Main Methods:

  • Fabrication of aligned poly(ε-caprolactone) (PCL) microfibrous scaffolds using controlled fiber-drawing.
  • In vitro biocompatibility testing with fibroblasts (adhesion, proliferation).
  • In vivo evaluation in rabbits with abdominal wall incisions, followed by mechanical, histological, and immunohistochemical analyses.

Main Results:

  • The aligned PCL scaffold demonstrated excellent in vitro cell attachment and proliferation.
  • In vivo implantation significantly improved the tensile modulus of the repaired abdominal wall.
  • Histological analyses showed enhanced collagen deposition and increased microvessel density in scaffold-treated areas.

Conclusions:

  • The aligned PCL microfibrous scaffold effectively improved the mechanical properties and biological quality of abdominal wall healing.
  • This scaffold shows potential for clinical application in reducing incisional hernia formation.