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[Asymptomatic osteonecrosis of the hip in HIV-infected patients]

José Luis Lamas1, Antonio Ocampo, César Martínez-Vázquez

  • 1Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Complejo Hospitalario Universitario de Vigo, Hospital Xeral, Universidad de Santiago de Compostela, Vigo, Pontevedra, España.

Enfermedades Infecciosas Y Microbiologia Clinica
|August 18, 2009
PubMed

Insights

The prevalence of silent osteonecrosis of the hip in human immunodeficiency virus (HIV)-infected patients is 4.1%. Key risk factors include corticosteroid treatment, lower CD4 counts, and AIDS-defining illness.

Area of Science:

  • Orthopedics
  • Infectious Diseases
  • Radiology

Context:

  • Osteonecrosis (ON) of the hip is a known complication in patients with human immunodeficiency virus (HIV).
  • Potential risk factors include corticosteroid use, dyslipidemia, alcoholism, lipodystrophy, antiretroviral drugs, and HIV infection itself.
  • Evaluating silent ON in HIV patients is crucial for understanding disease progression and management.

Purpose:

  • To determine the prevalence of asymptomatic osteonecrosis (ON) of the hip in HIV-infected patients.
  • To investigate the association between ON of the hip and various risk factors in this population.

Summary:

  • A magnetic resonance imaging (MRI) study was conducted on 97 HIV-infected patients (aged 20-70) who met specific inclusion criteria.
  • Osteonecrosis of the hip was detected in 4 patients (4.1%), all of whom were male.
  • Significant differences were observed in CD4 lymphocyte nadir, CDC stage C prevalence, and prior corticosteroid treatment between patients with and without ON.

Impact:

  • The study identified a 4.1% prevalence of asymptomatic osteonecrosis of the hip in HIV-infected individuals.
  • Corticosteroid treatment, lower CD4 lymphocyte nadir, and AIDS-defining disease emerged as significant risk factors.
  • Antiretroviral treatment did not show an association with osteonecrosis in this cohort.
Abstract

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