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Updated: Jun 20, 2026

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury
Published on: February 10, 2026
Epidemiology of acute renal failure in ICUs: a multi-center prospective study
Emilios Andrikos1, Paraskevi Tseke, Olga Balafa
1Department of Nephrology, Hatzikosta Hospital, Ioannina, Greece.
Background And Aim:
Acute kidney injury (AKI) is a common complication in intensive care units (ICUs). However, its incidence and outcome vary in several studies depending on definitions used or even the geographic origin of the study. We aimed to evaluate the epidemiology of AKI in ICUs in Greece.
Method:
Prospective multicenter study of ICU patients presented with AKI during a 3-month period.
Results:
One-hundred and seventy patients presented with AKI (16% of total admissions in 23 ICUs). The most common contributing factor to AKI was sepsis (45%). Half of the patients required renal replacement therapy, which was mainly managed by ICU clinicians. Nearly 65% of the AKI patients died, whereas 15% were discharged with renal impairment. Age (RR 1.01, p = 0.046), sepsis (RR 1.62, p = 0.015) and urine output (RR 0.99, p = 0.009) were independently associated with outcome.
Conclusion:
AKI involves a large number of patients in Greek ICUs and is associated with adverse outcomes.
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