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Anchor sequence-dependent endogenous processing of human immunodeficiency virus 1 envelope glycoprotein gp160 for
M Polydefkis1, S Koenig, C Flexner
1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
The Journal of Experimental Medicine
|March 1, 1990
Abstract:
Human CD4+ T cell clones and cell lines were shown to lyse recombinant vaccinia virus-infected cells that synthesize the HIV-1 envelope glycoprotein gp160. The processing of endogenously synthesized gp160 for recognition by CD4+ T cells required that the protein, after synthesis on the rough endoplasmic reticulum and during subsequent cellular transport, remain attached to the luminal/extracellular membrane face by a hydrophobic anchor sequence.