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Telomerase deficiency affects normal brain functions in mice.

Jaehoon Lee1, Yong Sang Jo, Young Hoon Sung

  • 1Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 440-746, Korea.

Neurochemical Research
|August 18, 2009
PubMed
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Telomerase reverse transcriptase (TERT) is crucial for normal brain function, particularly in the hippocampus and olfactory bulbs. TERT deficiency in mice led to altered anxiety and olfaction, highlighting its role in these brain regions.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Telomerase is vital for maintaining telomere structure, chromosome stability, and stem/progenitor cell characteristics.
  • Adult neurogenesis relies on neural stem and progenitor cells in the hippocampus and olfactory bulbs throughout life.

Purpose of the Study:

  • To investigate the role of telomerase in maintaining normal brain functions in vivo.
  • To examine the expression patterns of telomerase components (TERT and TERC) in different brain regions.

Main Methods:

  • Analysis of telomerase reverse transcriptase (TERT) and telomerase RNA component (TERC) expression in mouse brain.
  • Behavioral testing of TERT-deficient mice, focusing on hippocampus- and olfactory bulb-dependent functions.
  • Assessment of cerebellum-dependent behaviors in TERT-deficient mice.

Main Results:

  • TERT expression was detected in the hippocampus, olfactory bulbs, and cerebellum.
  • TERC was not detected in the hippocampus and olfactory bulbs.
  • TERT-deficient mice showed significantly altered anxiety-like behaviors and impaired olfaction.
  • Cerebellum-dependent behaviors remained unchanged in TERT-deficient mice.

Conclusions:

  • TERT is constitutively expressed in the hippocampus and olfactory bulbs.
  • TERT plays a critical role in regulating normal brain functions, specifically those associated with the hippocampus and olfactory bulbs.
  • The findings suggest a region-specific function of TERT in the adult brain.