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Related Experiment Video

Updated: Jun 20, 2026

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

Bioactive Nortriterpenoids from Schisandra grandiflora.

Wei-Lie Xiao¹, Yan-Qing Gong, Rui-Rui Wang

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.

Journal of Natural Products

|August 19, 2009

Summary

Three new nortriterpenoids, schigrandilactones A-C, were isolated from Schisandra grandiflora. Compounds 1 and 2 showed cytotoxicity against cancer cells, while compound 3 inhibited HIV-1.

Related Experiment Videos

Last Updated: Jun 20, 2026

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

Area of Science:

Natural Product Chemistry
Medicinal Chemistry
Pharmacology

Background:

Schisandra grandiflora is a plant source of bioactive compounds.
Nortriterpenoids are a class of natural products with diverse biological activities.

Purpose of the Study:

To isolate and characterize new nortriterpenoids from Schisandra grandiflora.
To evaluate the cytotoxic and anti-HIV-1 activities of isolated compounds.

Main Methods:

Isolation of compounds using organic solvent extraction.
Structure elucidation of new compounds using spectroscopic methods and X-ray crystallography.
Assessment of cytotoxic activity against human cancer cell lines.
Evaluation of anti-human immunodeficiency virus type 1 (anti-HIV-1) inhibition.

Main Results:

Three new nortriterpenoids, schigrandilactones A-C (1-3), were identified.
Compounds 1 and 2 possess a spirocyclic moiety; compound 3 has a novel oxygenation pattern.
Relative configurations of compounds 1 and 3 were confirmed by single-crystal X-ray diffraction.
Compounds 1 and 2 exhibited cytotoxicity against two human cancer cell lines.
Compound 3 demonstrated anti-HIV-1 inhibitory activity in infected C8166 cells.

Conclusions:

The study successfully isolated and characterized novel nortriterpenoids from Schisandra grandiflora.
Schigrandilactones A-C possess significant cytotoxic and anti-HIV-1 activities, warranting further investigation.