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Related Experiment Videos

DNA methylation and epigenetic inheritance.

R Holliday1

  • 1CSIRO Laboratory for Molecular Biology, North Ryde, New South Wales, Australia.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|January 30, 1990
PubMed
Summary
This summary is machine-generated.

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Epigenetics controls gene activity during development. DNA methylation and demethylation are key mechanisms, offering insights into gene silencing and reactivation for complex organism development.

Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Background:

  • Classical genetics explains gene transmission but not developmental gene regulation.
  • Epigenetics studies mechanisms controlling gene activity temporally and spatially during development.

Purpose of the Study:

  • To clarify rules of gene silencing and reactivation via DNA methylation and demethylation.
  • To understand epigenetic control of gene expression in developing and adult organisms.

Main Methods:

  • Studying epigenetic changes in DNA methylation in cultured mammalian cells.
  • Isolating and characterizing mutants with altered DNA methylase activity.

Main Results:

  • Experimental systems provide means to clarify DNA methylation's role in gene silencing and reactivation.

Related Experiment Videos

  • General principles of epigenetic mechanisms, including gene expression instability and stable heritability, are defined.

    • Conclusions:

    • DNA methylation and demethylation are fundamental to epigenetic mechanisms.
    • Epigenetic determination of gene expression can be reversed in the germ line, impacting development.