Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Patch Clamp01:18

Patch Clamp

Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...
Types of Hypothesis Testing01:11

Types of Hypothesis Testing

There are three types of hypothesis tests: right-tailed, left-tailed, and two-tailed.
When the null and alternative hypotheses are stated, it is observed that the null hypothesis is a neutral statement against which the alternative hypothesis is tested. The alternative hypothesis is a claim that instead has a certain direction. If the null hypothesis claims that p = 0.5, the alternative hypothesis would be an opposing statement to this and can be put either p > 0.5, p < 0.5, or p ≠ 0.5.
Long-patch Base Excision Repair01:02

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
Non-destructive Tests for Concrete Strength01:12

Non-destructive Tests for Concrete Strength

The rebound hammer test, also known as the Schmidt hammer test, is a non-destructive technique for evaluating the hardness of concrete and, indirectly, the strength of concrete. It operates on the principle that the rebound of a spring-driven mass from a concrete surface correlates to the surface's hardness. The device comprises a mass within a tubular housing, a spring mechanism, and a plunger that strikes the concrete. Upon release, the energy imparted to the mass by the spring causes it to...
Null and Alternative Hypotheses01:16

Null and Alternative Hypotheses

The actual hypothesis testing begins by considering two hypotheses. They are termed  the null hypothesis and the alternative hypothesis. These hypotheses contain opposing viewpoints.
The null hypothesis, denoted by H0 is a statement of no difference between the variables—they are not related. This can often be considered the status quo. As  a result if you cannot accept the null, it requires some action.
The alternative hypothesis, denoted by H1 or Ha, is a claim about the population that is...
Multiple Comparison Tests01:13

Multiple Comparison Tests

Multiple comparison test, abbreviated as MCT, is a post hoc analysis generally performed after comparing multiple samples with one or more tests. An MCT will help identify a significantly different sample among multiple samples or a factor among multiple factors.
It would be easy to compare two samples using a significance alpha level of 0.05. In other words, there is only one sample pair to be compared. However, it would be difficult to identify a significantly different sample if the number...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Does ECT raise the risk of a recurrent stroke?]

Tijdschrift voor psychiatrie·2023
Same author

Time for a change.

The British journal of dermatology·2021
Same author

Position statement: The need for EU legislation to require disclosure and labelling of the composition of medical devices.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

The presence of sulfites in 'natural rubber latex' and 'synthetic' rubber gloves: an experimental pilot study.

The British journal of dermatology·2019
Same author

The epidemic of methylisothiazolinone contact allergy in Europe: follow-up on changing exposures.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

Isothiazolinone derivatives and allergic contact dermatitis: a review and update.

Journal of the European Academy of Dermatology and Venereology : JEADV·2018
Same journal

2024 guidelines (S3) for the therapeutic management of patients with genital herpes.

Annales de dermatologie et de venereologie·2026
Same journal

Topical JAK inhibitors in the lichen planus spectrum: a systematic review.

Annales de dermatologie et de venereologie·2026
Same journal

2024 recommendations for the therapeutic management of anogenital warts.

Annales de dermatologie et de venereologie·2026
Same journal

Successful use of thalidomide in treating metastatic Crohn's disease.

Annales de dermatologie et de venereologie·2026
Same journal

Multiple cutaneous juvenile xanthogranuloma: a monocentric study.

Annales de dermatologie et de venereologie·2026
Same journal

Cartilage-hair-hypoplasia associated with granulomatosis induced by rubella vaccine.

Annales de dermatologie et de venereologie·2026
See all related articles

Related Experiment Video

Updated: Jun 20, 2026

A Cost Effective and Adaptable Scratch Migration Assay
08:59

A Cost Effective and Adaptable Scratch Migration Assay

Published on: June 30, 2020

[Alternatives to patch tests].

A Goossens1

  • 1Unité d'allergie de contact, département de dermatologie, hôpital universitaire Saint-Raphaël, Katholieke Universiteit Leuven, Kapucijnenvoer 33, 3000 Leuven, Belgique. an.goossens@uz.kuleuven.ac.be

Annales De Dermatologie Et De Venereologie
|August 19, 2009
PubMed
Summary
This summary is machine-generated.

Patch testing is the most reliable method for identifying contact allergens. However, alternative tests like the semi-open test and repeated open application test (ROAT) may be more suitable in specific situations.

More Related Videos

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
17:28

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

Related Experiment Videos

Last Updated: Jun 20, 2026

A Cost Effective and Adaptable Scratch Migration Assay
08:59

A Cost Effective and Adaptable Scratch Migration Assay

Published on: June 30, 2020

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
17:28

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

Area of Science:

  • Dermatology
  • Allergology
  • Contact Dermatitis Research

Context:

  • Accurate identification of contact allergens is crucial for managing allergic contact dermatitis.
  • Standard patch testing and patient-provided product analysis are established diagnostic methods.
  • Limitations of standard patch testing exist in certain clinical scenarios.

Purpose:

  • To evaluate the reliability of standard patch testing versus alternative methods for contact allergen identification.
  • To determine when semi-open tests or repeated open application tests (ROAT) are more appropriate than standard patch testing.
  • To provide guidance on selecting the optimal diagnostic method for suspected contact allergies.

Summary:

  • Patch testing, utilizing standard and specific allergen series, alongside patient-derived product ingredients, remains the gold standard for diagnosing contact allergens.
  • While highly reliable, patch testing may not be the optimal approach for all cases.
  • The semi-open test and the repeated open application test (ROAT) offer valuable alternatives under specific circumstances, enhancing diagnostic accuracy.

Impact:

  • Improved diagnostic strategies for contact dermatitis.
  • More precise identification of causative allergens, leading to better patient management.
  • Potential reduction in misdiagnosis and delayed treatment of allergic contact dermatitis.