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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
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Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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Related Experiment Video

Updated: Jun 20, 2026

Isolation and Characterization of Microvesicles from Peripheral Blood
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Isolation and Characterization of Microvesicles from Peripheral Blood

Published on: January 6, 2017

Cell-derived microvesicles and cancer.

F F van Doormaal1, A Kleinjan, M Di Nisio

  • 1Departments of Vascular Medicine and Clinical Chemistry, Academic Medical Centre, Amsterdam, the Netherlands. F.F.vanDoormaal@amc.uva.nl

The Netherlands Journal of Medicine
|August 19, 2009
PubMed
Summary

Cell-derived microvesicles in body fluids are linked to cancer progression and metastasis. Research highlights their role in cancer survival, invasiveness, and potential use in patient risk stratification and treatment strategies.

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Area of Science:

  • Oncology
  • Hematology
  • Cell Biology

Background:

  • Cell-derived microvesicles have been observed in cancer patients since the 1970s.
  • A prothrombotic state in cancer patients is consistently associated with microvesicle presence.
  • Emerging evidence implicates microvesicles in key aspects of cancer progression.

Purpose of the Study:

  • To provide a comprehensive overview of microvesicle contributions to cancer development.
  • To discuss the role of microvesicles in cancer cell survival and invasiveness.
  • To explore the utility of microvesicles in cancer patient risk stratification and treatment.

Main Methods:

  • Literature review of studies on microvesicles in cancer.
  • Analysis of evidence linking microvesicles to cancer cell survival and metastasis.
  • Discussion of current and potential clinical applications of microvesicles.

Main Results:

  • Microvesicles significantly contribute to cancer cell survival, invasiveness, and metastasis.
  • The presence of microvesicles is a long-standing indicator of a prothrombotic state in cancer patients.
  • Microvesicles show promise for risk stratification and therapeutic strategies in oncology.

Conclusions:

  • Microvesicles play a multifaceted role in promoting cancer development and progression.
  • Understanding microvesicle functions offers insights into cancer pathophysiology.
  • Microvesicles represent a potential biomarker and therapeutic target in cancer care.