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Updated: Jun 20, 2026

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models
Published on: March 1, 2015
A child with difficulty swallowing
Andrew Pittard1, Thomas J Abramo, Donald H Arnold
1Departments of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA.
Insights
Difficulty swallowing in children can signal acute disseminated encephalomyelitis (ADEM). This case highlights the need for broader differential diagnoses beyond common causes when symptoms persist.
Area of Science:
- Pediatric Neurology
- Infectious Diseases
- Demyelinating Diseases
Background:
- Difficulty swallowing (dysphagia) is a frequent emergency department complaint in children.
- Acute disseminated encephalomyelitis (ADEM) is a rare, immune-mediated demyelinating disorder.
- ADEM typically follows an infection or vaccination, presenting with encephalopathy and neurological deficits.
Observation:
- A male child presented with dysphagia as the initial symptom.
- Standard evaluations for common causes of dysphagia were inconclusive.
- The child was subsequently diagnosed with ADEM.
Findings:
- This case illustrates dysphagia as an unusual early presentation of ADEM.
- ADEM is characterized by widespread inflammation and demyelination in the central nervous system.
- Neurologic manifestations of ADEM are typically multifocal and acute or subacute.
Implications:
- Pediatricians and emergency physicians should consider ADEM in children with unexplained dysphagia.
- Early recognition of ADEM is crucial for timely intervention and management.
- This case underscores the importance of considering less common diagnoses for persistent, unexplained symptoms.
Abstract:
Difficulty swallowing is a common presenting complaint among children seen in the emergency department. We report a case of a male child who presented with difficulty swallowing as the first manifestation of acute disseminated encephalomyelitis and review the pathogenesis and clinical manifestations of this disease. Acute disseminated encephalomyelitis is typically a monophasic, postinfectious, demyelinating disease that presents most often with encephalopathy and acute or subacute, multifocal neurologic deficits. The case demonstrates the importance of considering alternate diagnoses when presented with a patient having a common symptom for which evaluation does not provide a plausible cause.
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