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Controlled Synthesis and Fluorescence Tracking of Highly Uniform Poly(N-isopropylacrylamide) Microgels
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Fluorescent polyacrylamide nanoparticles for naproxen recognition.

Alejandro Lapresta-Fernández1, Piotr J Cywinski, Artur J Moro

  • 1Institute of Physical Chemistry, Friedrich-Schiller-University Jena, Lessingstrasse 10, 07743, Jena, Germany. alejandro.lapresta@uni-jena.de

Analytical and Bioanalytical Chemistry
|August 19, 2009
PubMed
Summary
This summary is machine-generated.

We developed fluorescent acrylamide nanoparticles (FANs) that detect non-steroidal anti-inflammatory drugs (NSAIDs) like naproxen. These nanosensors use fluorescence changes to quantify naproxen in aqueous solutions.

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Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Nanotechnology

Background:

  • Non-steroidal anti-inflammatory drugs (NSAIDs), such as naproxen, are widely used for pain, fever, and inflammation.
  • Developing selective and sensitive nanosensors for NSAID detection is crucial for therapeutic drug monitoring and environmental analysis.

Purpose of the Study:

  • To synthesize and characterize fluorescent acrylamide nanoparticles (FANs) for the recognition of naproxen.
  • To investigate the fluorescence-based detection mechanism of naproxen using the developed FANs.

Main Methods:

  • Inverse microemulsion polymerization was employed to create FANs using acrylamide and a fluorescent monomer (mDMASP).
  • Surfactants (Brij 30, sodium bis(2-ethylhexyl)sulfosuccinate) and hexane were used in the polymerization process.
  • Nanoparticle characterization included size distribution analysis and fluorescence spectroscopy.

Main Results:

  • The synthesized FANs exhibited absorbance at ~460 nm and fluorescence emission at 590 nm.
  • A concentration-dependent increase in fluorescence at 590 nm was observed upon the addition of naproxen, indicating successful recognition via ionic interactions.
  • The FANs demonstrated a hydrodynamic diameter of 34 nm and a size distribution of 20-80 nm.
  • Selectivity studies were performed to evaluate potential interference from other drugs and biomolecules.

Conclusions:

  • Fluorescent acrylamide nanoparticles (FANs) were successfully synthesized for the detection of naproxen.
  • The FANs show potential as a sensitive and selective fluorescent nanosensor for NSAID detection in aqueous solutions.
  • The fluorescence enhancement mechanism allows for quantitative analysis of naproxen based on ionic interactions.