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Updated: Jun 20, 2026
Quantification of Atherosclerosis in Mice
Published on: June 12, 2019
[Effect of dietary Lactobacillus casei on cholesterol metabolism in apoE-deficient mice]
Zhihong Tang1, Huilian Zhu, Min Xia
1School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. tangzhh@mail.sysu.edu.cn
Objective:
To explore the effect of dietary Lactobacillus casei on cholesterol metabolism in apoE-deficient mice in order to find the possible active components of Lactobacillus casei in anti-atherogenesis.
Methods:
ApoE-deficient mice were randomly divided into 4 groups: control group (A), Lactobacillus casei 10(8) cfu/ml group (B), Lactobacillus casei 10(10) cfu/ml group (C), Lactobacillus casei 10(12) cfu/ml group (D). ApoE-deficient mice were administrated with dietary contenting Lactobacillus casei for 16 weeks and the cholesterol levels of serum, liver, aorta in different groups were determined by enzymatic method.
Results:
When compared with control group, total cholesterol accumulation in aortas and livers showed a significant reduction in dietary mice fed with contenting Lactobacillus casei (P < 0.05). At the same time, it had higher HDL-C level compared to control group.
Conclusion:
This result suggested that Lactobacillus casei could have the capacity of improvement.
