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Related Experiment Videos

Neutrophil function in healthy elderly subjects.

R R MacGregor1, M Shalit

  • 1Infectious Diseases Section, University of Pennsylvania School of Medicine.

Journal of Gerontology
|March 1, 1990
PubMed
Summary
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Elderly neutrophils show impaired in vivo delivery and reduced response to stimulation, despite normal resting function. This suggests age-related defects in neutrophil mediator responsiveness and immune function.

Area of Science:

  • Immunology
  • Gerontology
  • Cellular Biology

Background:

  • Neutrophil function is critical for host defense.
  • Aging may impact immune cell function, affecting susceptibility to infections.

Purpose of the Study:

  • To investigate neutrophil function in healthy elderly individuals compared to young controls.
  • To identify age-related changes in neutrophil adherence, migration, and responsiveness.

Main Methods:

  • Neutrophil function tests including adherence, migration, chemiluminescence, and glycoprotein expression (CD11).
  • In vivo assessment of neutrophil delivery to skin abrasions.
  • Measurement of serum immunoglobulin (IgM) and complement (C3, C4, total hemolytic complement) levels.

Main Results:

Related Experiment Videos

  • Elderly neutrophils exhibited normal resting adherence, migration, and phagocytosis-induced chemiluminescence.
  • In vivo neutrophil delivery to skin abrasions was significantly reduced in the elderly.
  • Elderly neutrophils showed diminished upregulation of CD11 and adherence upon FMLP stimulation, with higher baseline CD11 expression.
  • Lower mean IgM levels and higher C3, C4, and total hemolytic complement concentrations were observed in the elderly.

Conclusions:

  • Healthy elderly individuals exhibit specific impairments in neutrophil in vivo delivery and mediator responsiveness.
  • Age-related changes in neutrophils may involve altered baseline expression and reduced functional responses to stimuli.
  • Complement system shows altered concentrations in elderly, warranting further investigation into its role in aging immunity.