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Respiratory syncytial virus (RSV) prevention and treatment: past, present, and future

Leonard E Weisman1

  • 1Baylor College of Medicine, and, Perinatal Center, Texas Children's Hospital, Houston, TX 77030, USA. lweisman@bcm.edu

Cardiovascular & Hematological Agents in Medicinal Chemistry
|August 20, 2009
PubMed

Insights

Respiratory syncytial virus (RSV) poses a significant global health threat, particularly to infants. This review covers past, present, and future prevention and treatment strategies for high-risk populations.

Area of Science:

  • Virology
  • Pediatrics
  • Infectious Diseases

Background:

  • Respiratory syncytial virus (RSV) is a major global pathogen causing recurrent infections throughout life.
  • Infants, especially those with pre-existing conditions, face significant morbidity and mortality from RSV.
  • Current treatments are limited, necessitating research into novel interventions.

Purpose of the Study:

  • To review the clinical aspects of RSV, focusing on high-risk infant populations.
  • To examine existing, emerging, and future prevention and treatment strategies for RSV in these vulnerable groups.
  • To serve as a comprehensive resource for clinicians and researchers.

Main Methods:

  • Literature review of clinical studies and research on RSV.
  • Analysis of current and pipeline therapeutic and prophylactic agents.
  • Focus on evidence-based strategies for high-risk infant populations.

Main Results:

  • Limited efficacy of current RSV treatments like Ribavirin.
  • Several novel therapeutic agents (e.g., RSV604, BTA9881, ALN-RSV01) are under investigation.
  • Established and developing preventive strategies (e.g., palivizumab, motavizumab, Medi-557) exist.

Conclusions:

  • RSV remains a critical concern, especially for high-risk infants.
  • A range of preventive and therapeutic options are evolving.
  • This review consolidates information on RSV management for clinicians and investigators.

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