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Updated: Jun 20, 2026

Imaging of HIV-1 Envelope-induced Virological Synapse and Signaling on Synthetic Lipid Bilayers
Published on: March 8, 2012
y Human herpesvirus 6 envelope components enriched in lipid rafts: evidence for virion-associated lipid rafts
Akiko Kawabata1, Huamin Tang, Honglan Huang
1Division of Biomedical Research, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan. akawabata@nibio.go.jp
Abstract:
In general, enveloped viruses are highly dependent on their lipid envelope for entry into host cells. Here, we demonstrated that during the course of virus maturation, a significant proportion of human herpesvirus 6 (HHV-6) envelope proteins were selectively concentrated in the detergent-resistant glycosphingolipid- and cholesterol-rich membranes (rafts) in HHV-6-infected cells. In addition, the ganglioside GM1, which is known to partition preferentially into lipid rafts, was detected in purified virions, along with viral envelope glycoproteins, gH, gL, gB, gQ1, gQ2 and gO indicating that at least one raft component was included in the viral particle during the assembly process.
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