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Pattern of liver diseases in Oman
T T Al-Lawati1, M George, F A R Al-Lawati
1Division of Child Health, Royal Hospital, Muscat, Sultanate of Oman. tawfiqtaki@hotmail.com
Annals of Tropical Paediatrics
|August 20, 2009
Summary
Consanguineous marriage in Oman is linked to a high incidence of genetic liver diseases in children. Progressive familial intrahepatic cholestasis and fibrocystic liver disease are common, necessitating specialized care.
Area of Science:
- Pediatric Hepatology
- Medical Genetics
- Public Health
Background:
- Consanguineous marriage is prevalent in Arab Gulf countries, including Oman.
- This practice is associated with an increased frequency of genetic disorders, particularly liver diseases in children.
Purpose of the Study:
- To characterize the patterns of chronic liver diseases in Omani children.
- To identify the most common genetic liver disorders and their associated complications.
Main Methods:
- Retrospective analysis of pediatric chronic liver disease cases at The Royal Hospital, Oman.
- Data collected from January 2005 to January 2007.
Main Results:
- Seventy-nine children with chronic liver disease were identified.
- The most frequent disorders were progressive familial intrahepatic cholestasis (30%) and fibrocystic disease of liver and kidney (21%).
- High rates of consanguinity (78%) and complications like growth retardation (75%) were observed.
Conclusions:
- Approximately 50% of chronic liver disorders in Oman have a hereditary basis.
- An estimated three children annually require liver transplantation due to these conditions.
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