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Updated: Jun 20, 2026
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Induction of Ocular Surface Inflammation and Collection of Involved Tissues
Published on: August 4, 2022
Idiopathic sclerosing orbital inflammation--a case series study
Yan-Ming Chen1, Fung-Rong Hu, Shu-Lang Liao
1Department of Ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Summary
Idiopathic sclerosing orbital inflammation (ISOI) is a rare condition. Early treatment combining steroids, immunosuppressants, and surgery may help manage this challenging disease.
Area of Science:
- Ophthalmology
- Pathology
Background:
- Idiopathic sclerosing orbital inflammation (ISOI) is a rare orbital disease.
- Diagnosis and management of ISOI can be challenging.
Purpose of the Study:
- To review the clinical features, treatments, and outcomes of patients with ISOI in Taiwan.
Main Methods:
- Retrospective review of patients diagnosed with ISOI between 1995 and 2007.
- Analysis of clinical presentation, treatment modalities, efficacy, and outcomes.
Main Results:
- Nine patients (6 male, 3 female) aged 33-82 were included.
- Common symptoms: pain and blurred vision (77.8%). Common signs: reduced visual acuity and proptosis (89%).
- Combination therapy (steroids/immunosuppressants with surgery) showed better outcomes than monotherapy.
Conclusions:
- ISOI is rare and difficult to diagnose and manage.
- Early intervention with steroids/immunosuppressants and surgical debulking may control or regress the disease.
