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Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
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Published on: March 20, 2015

Ag-modified Au nanocavity SERS substrates.

Emiliano Cortés1, Nicolás G Tognalli, Alejandro Fainstein

  • 1Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Universidad Nacional de La Plata-CONICET, Sucursal 4 Casilla de Correo 16 (1900), La Plata, Argentina.

Physical Chemistry Chemical Physics : PCCP
|August 20, 2009
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel method to enhance Surface-Enhanced Raman Spectroscopy (SERS) substrates by coating durable gold (Au) nanocavities with thin silver (Ag) layers. This combination yields highly sensitive and stable SERS detection, improving signal amplification.

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Ultrafast Laser-Ablated Nanoparticles and Nanostructures for Surface-Enhanced Raman Scattering-Based Sensing Applications

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Area of Science:

  • Plasmonics and Nanophotonics
  • Surface-Enhanced Raman Spectroscopy (SERS)
  • Materials Science

Background:

  • Cavity void metallic arrays enable tuning of plasmon-polariton modes across a wide spectral range.
  • Gold (Au) nanocavity substrates offer excellent reproducibility and stability.
  • Silver (Ag) nanostructures provide significantly higher SERS enhancement factors.

Purpose of the Study:

  • To combine the stability of Au nanocavities with the high enhancement of Ag for SERS applications.
  • To investigate the effect of ultrathin Ag layer deposition on Au nanocavity SERS performance.

Main Methods:

  • Fabrication of 500 nm Au-nanocavity templates.
  • Controlled electrochemical deposition of ultrathin Ag layers (approx. skin-depth) onto Au templates.
  • SERS signal amplification measurement using 4-mercaptopyridine as a molecular probe.

Main Results:

  • Ultrathin Ag layer modification of Au nanocavities resulted in strong SERS signal amplification.
  • Enhanced SERS signals were observed in both red and green spectral regions.
  • A spectral shift in Raman resonance scans indicated Ag-induced changes in plasmon-polariton response.

Conclusions:

  • The developed method provides a versatile platform for creating renewable SERS-active substrates.
  • This approach successfully merges the durability of Au with the enhanced SERS amplification of Ag.
  • The findings pave the way for improved SERS applications requiring both high sensitivity and substrate longevity.