Related Experiment Videos

Inflammation, overhydration and cardiac biomarkers in haemodialysis patients: a longitudinal study

Leo H Jacobs1, Jos J van de Kerkhof, Alma M Mingels

  • 1Department of Clinical Chemistry, University Hospital Maastricht, Maastricht, the Netherlands. leo.jacobs@mumc.nl

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|August 21, 2009
PubMed

Insights

Body composition impacts cardiac biomarkers in hemodialysis patients. Fluid distribution, malnutrition, and inflammation are linked to natriuretic peptides and cardiac markers, suggesting potential for intervention.

Area of Science:

  • Nephrology
  • Cardiology
  • Biomarkers

Background:

  • Inflammation, overhydration, and elevated cardiac biomarkers impact outcomes in hemodialysis (HD) patients.
  • Longitudinal relationships between body composition (BC), inflammation, and cardiac biomarkers in HD patients require further exploration.

Purpose of the Study:

  • To investigate the longitudinal relationship between body composition (BC) and cardiac biomarker concentrations in hemodialysis patients.
  • To explore the interplay between body composition, inflammation, and cardiac biomarkers in the HD population.

Main Methods:

  • 44 HD patients were followed for 6 months.
  • Body composition assessed using multifrequency bioimpedance (BIA).
  • Serum concentrations of cardiac troponin T (cTnT), hsCRP, BNP, and NT-proBNP measured bi-monthly; longitudinal analysis using a marginal model.

Main Results:

  • BC parameters significantly predicted BNP and NT-proBNP, independent of gender, time, hsCRP, and cTnT.
  • Intracellular water/body weight ratio (malnutrition indicator) negatively affected BNP/NT-proBNP; extracellular water/body weight ratio (overhydration indicator) positively affected them.
  • HsCRP and cTnT were associated; NT-proBNP predicted cTnT and hsCRP.

Conclusions:

  • BIA-derived BC parameters significantly correlate with natriuretic peptide concentrations in HD patients.
  • Natriuretic peptide levels may be modifiable by altering fluid distribution, irrespective of cardiac history.
  • A complex relationship exists between overhydration, malnutrition, inflammation, and cardiac biomarkers in dialysis patients.
Abstract

Related Concept Videos

Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this measurement...
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...