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DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
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Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
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Peritoneal dialysis (PD) is a procedure that facilitates the exchange of solutes, waste products, electrolytes, and excess fluid between the blood in the peritoneal capillaries and a dialysis solution introduced into the peritoneal cavity.Principles of Peritoneal Dialysis (PD)Diffusion: Waste products such as urea and electrolytes move from high concentrations in the blood to low concentrations in the dialysate across the peritoneal membrane. This mechanism is driven by the concentration...
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Creating a Globally Distributed Multinational Dialysis Database - The ApolloDialDb Initiative.

Melanie Wolf1, Yue Jiao1, Kaitlyn Croft1

  • 1Renal Research Institute, New York, New York, USA.

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|November 24, 2025
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Summary
This summary is machine-generated.

A new global dialysis database, Apollo, was created from over 543,000 patients in 40 countries. This anonymized dataset enables real-world research and advances understanding of kidney disease and dialysis therapies.

Keywords:
end-stage kidney diseasemultinational databaseoutcomes

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Area of Science:

  • Nephrology
  • Data Science
  • Public Health

Background:

  • Multinational dialysis datasets are scarce due to data harmonization and privacy challenges.
  • Fresenius Medical Care developed ApolloDialDb (Apollo), an anonymized global dialysis database.
  • This database addresses the need for harmonized, worldwide clinical data in nephrology.

Purpose of the Study:

  • To report the approach used for creating a multinational anonymized dialysis database.
  • To detail the characteristics of dialysis patients globally within this new database.
  • To establish a resource for real-world research and data analytics in kidney care.

Main Methods:

  • Extracted and harmonized routinely collected clinical data from dialysis clinics worldwide.
  • Anonymized data following a rigorous reidentification risk assessment by an external company.
  • Consolidated and stored data in a central cloud environment for periodic updates.

Main Results:

  • Apollo database covers 543,169 patients across 40 countries from January 2018 to March 2021.
  • Includes extensive demographic, laboratory, treatment, medication, and clinical outcome data.
  • Reveals regional variations in patient age, treatment modality, and treatment duration.

Conclusions:

  • The Apollo database provides a robust resource for real-world research and AI model development in nephrology.
  • Facilitates a deeper understanding of kidney disease and dialysis therapies.
  • Serves as a valuable comparative resource for the global nephrology community.