Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Imaging Studies II: Ultrasonography

Imaging Studies II: Ultrasonography

IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...

Imaging Studies III: Computed Tomography

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

Radiological Investigation I: X-ray and CT

Radiological Investigation I: X-ray and CT

Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

AI-Driven Bone and Marrow Segmentation on FLT-PET/CT: Technical Multi-organ Validation in AML and HCT.

Research square·2026

Same author

Self-Compassion and Achievement Goals: A Curvilinear Examination Using Generalized Additive Modeling.

Psychological reports·2026

Same author

Development and Potent Anti-Tumor Activity of a Fully Humanized Anti-TAG-72-IL-2 Fusion Protein for Therapy of Solid Tumors.

Cancers·2025

Same author

Proton Density Fat Fraction Micro-MRI for Non-Invasive Quantification of Bone Marrow Aging and Radiation Effects in Mice.

Bioengineering (Basel, Switzerland)·2025

Same author

CD33-D2 isoform characterization for advancement of its therapeutic potential.

Immunotherapy·2025

Same author

Development of Proton Density Fat Fraction Micro-MRI for Non-Invasive Quantitative Assessment of Bone Marrow Changes with Age and Radiation in Mouse Models.

bioRxiv : the preprint server for biology·2025

Search research articles

Related Experiment Video

Updated: Jun 20, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Assessing prostate, bladder and rectal doses during image guided radiation therapy--need for plan adaptation?

Raj Varadhan^1,2, Susanta K Hui², Sarah Way¹

¹Minneapolis Radiation Oncology, North Radiation Therapy Center, Robbinsdale, MN, U.S.A.

Journal of Applied Clinical Medical Physics

|August 21, 2009

Summary

Image Guided Radiotherapy (IGRT) for prostate cancer uses daily imaging to track organ movement. Adapting treatment plans with daily imaging, like on the Tomotherapy system, ensures accurate radiation doses are delivered to the tumor while sparing healthy organs.

More Related Videos

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

Related Experiment Videos

Last Updated: Jun 20, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

Area of Science:

Medical Physics
Radiation Oncology
Radiotherapy Technology

Background:

Image Guided Radiotherapy (IGRT) is crucial for precise dose delivery in localized prostate cancer treatment.
In-room imaging (CT) allows for daily tracking of prostate, bladder, and rectum anatomy to adjust radiation therapy.
Inter-fraction organ motion introduces dosimetric uncertainties that need evaluation.

Purpose of the Study:

To evaluate dosimetric uncertainties caused by inter-fraction organ variation during IGRT for prostate cancer.
To assess the accuracy of dose recomputation using daily CT scans from different imaging modalities.
To investigate the feasibility of adaptive radiotherapy planning based on daily image feedback.

Main Methods:

Compared kilovoltage cone beam CT (kvCBCT) on Elekta Synergy and Megavoltage CT (MVCT) on Tomotherapy Hi-ART for 10 patients.
Performed dose recomputation using daily CT anatomy and evaluated image quality using phantoms (ComTom, Catphan 600).
Utilized Planned Adaptive software on Tomotherapy to construct cumulative Dose Volume Histograms (DVHs) and adapt plans.

Main Results:

Direct dose recomputation on kvCBCT was inaccurate due to CT number deviations.
Maximum deviation to the prostate was 2.7% with kvCBCT.
Significant daily variations observed in rectum (up to 12%) and bladder (up to 40%) doses without adaptation.
Tomotherapy's adaptive planning with MVCT enabled delivered doses to closely match planned doses.

Conclusions:

IGRT requires careful consideration of imaging modality accuracy for dose recomputation.
Adaptive planning, particularly with systems like Tomotherapy using daily MVCT, is effective in managing organ variations.
Adaptive strategies ensure accurate dose delivery and improve treatment outcomes in prostate cancer radiotherapy.