Maternal obesity, associated complications and risk of prematurity
1Department of Newborn Services, The George Washington University Medical Center, Washington, DC 20037, USA. haly@mfa.gwu.edu
Insights
Maternal obesity and morbid obesity did not directly increase prematurity rates. Instead, associated medical conditions in obese women were linked to preterm birth. Adequate prenatal care may help manage these risks.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Public Health
Background:
- Maternal obesity is a growing concern in pregnancy.
- Understanding its impact on gestational age and birth outcomes is crucial.
- Previous studies suggest a link between obesity and prematurity.
Purpose of the Study:
- To examine obesity rates over 12 years.
- To assess the effect of maternal obesity on gestational age and birth weight.
- To determine if race influences the association between maternal obesity and preterm birth.
Main Methods:
- Retrospective analysis of 14,183 mother/infant pairs (1992-2003).
- Stratification by pre-pregnancy Body Mass Index (BMI): not obese (<30), obese (30-39), morbidly obese (≥40).
- Bivariate and multivariate analyses to control for confounding factors.
Main Results:
- Obesity (12%) and morbid obesity (3%) rates increased over time.
- Crude analysis showed higher prematurity rates in obese groups (16.7-20.3%) vs. non-obese (14.5%).
- After controlling for complications (smoking, anemia, hypertension, diabetes), obesity was not directly associated with prematurity.
Conclusions:
- No direct causal link found between maternal obesity and preterm birth.
- Medical complications common in obese women appear to be the primary drivers of prematurity.
- Further research is needed to evaluate prenatal care's role in mitigating prematurity in obese populations.
Objective:
We aimed at (a) examining the rates of obesity over a 12-year period; (b) studying the effect of obesity and morbid obesity on gestational age and birth weight and (c) determining the influence of race on the association between maternal obesity and the gestational age of a newborn.
Study Design:
We conducted a retrospective analysis using data from the perinatal data set of mothers delivering at the George Washington University between 1992 and 2003. We stratified mother/infant pairs (n=14 183) into three groups on the basis of maternal prepregnancy body mass index (BMI): not obese (BMI<30), obese (BMI 30 to 39) and morbidly obese (BMI> or =40). We identified all spontaneous and induced preterm deliveries in each group. Bivariate and multivariate analyses were conducted to control for significant differences between groups.
Result:
We identified obesity in 1707 (12%) and morbid obesity in 415 (3%) of the mothers. Obesity and morbid obesity increased over time during the study period. In crude analysis, mothers with obesity and morbid obesity were more likely to deliver prematurely (16.7 and 20.3%, respectively) when compared with nonobese women (14.5%), and were also more likely to have other complications including smoking, anemia, hypertension, diabetes and cesarean delivery. When controlling for these complications in a logistic regression model, obesity and morbid obesity were not associated with prematurity.
Conclusion:
There is no direct link between obesity and prematurity. Prematurity is more likely caused by medical complications that frequently occur in obese women. Further studies are needed on this growing population to test whether providing adequate prenatal care can control the associated medical conditions and subsequently ameliorate the rate of prematurity.
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