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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
Radical Autoxidation01:20

Radical Autoxidation

The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

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Related Experiment Video

Updated: Jun 20, 2026

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy
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Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy

Published on: May 26, 2023

Antioxidant therapy effectiveness: an up to date.

T Iannitti1, B Palmieri

  • 1Department of General Surgery and Surgical Specialties, Medical School and Surgical Clinic, University of Modena and Reggio Emilia, Modena, Italy. tommaso.iannitti@gmail.com

European Review for Medical and Pharmacological Sciences
|August 22, 2009
PubMed
Summary

Antioxidant compounds neutralize harmful free radicals, preventing cellular damage. However, current medical literature lacks consistent evidence to support their widespread clinical effectiveness.

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Design and Optimization Strategies of a High-Performance Vented Box
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Design and Optimization Strategies of a High-Performance Vented Box

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Cell Biology

Background:

  • Antioxidants protect cells from oxidative damage caused by free radicals.
  • Oxidative stress contributes to cellular damage across various tissues.
  • Numerous antioxidant products are available with diverse marketing claims.

Purpose of the Study:

  • To review the current state of antioxidant therapy.
  • To focus on evidence-based clinical applications of antioxidants.

Main Methods:

  • Literature review of published articles on antioxidant therapy.
  • Analysis of studies regarding the clinical use and effectiveness of antioxidants.

Main Results:

  • Heterogeneous published articles exist on antioxidant use.
  • Most studies lack comparability, hindering statistical significance for effectiveness.
  • Evidence-based clinical use remains a challenge.

Conclusions:

  • The clinical efficacy of antioxidant therapy requires further robust investigation.
  • Standardized research is needed to establish reliable evidence for antioxidant use.
  • A clear understanding of evidence-based antioxidant therapy is currently lacking.