Related Experiment Video
Updated: Jun 20, 2026
03:47
Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid
Published on: September 27, 2024
Common cosmeceuticals.
1The Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, OH 45252, USA. bissett.dl@pg.com
Clinics in Dermatology
|August 22, 2009
Summary
This review examines ten cosmeceutical agents, including vitamins, peptides, and ceramides, highlighting those with clinical data supporting topical skin appearance improvement effects for antiaging benefits.
Area of Science:
- Cosmetic science
- Dermatology
- Material science
Background:
- Cosmetic products frequently claim topical skin benefits, such as antiaging effects.
- A wide array of ingredients are utilized, necessitating a focused review of their efficacy.
- Clinical evidence is crucial for substantiating cosmetic ingredient claims.
Purpose of the Study:
- To review ten key cosmeceutical agents with documented clinical evidence for improving skin appearance.
- To focus on ingredients supported by scientific data rather than a comprehensive list.
- To provide an overview of vitamins, peptides, hydroxyl acids, sugar amines, ceramides, and metals used in cosmetics.
Main Methods:
- Selective review of available scientific literature.
- Focus on cosmeceutical agents with supporting clinical data.
- Categorization of agents into vitamins (A, B(3), C, E, panthenol), peptides, hydroxyl acids, sugar amines, ceramides, and metals.
Main Results:
- Identified ten categories of cosmeceutical agents with reported skin appearance benefits.
- Highlighted ingredients supported by clinical data for topical application.
- Vitamins (A, B(3), C, E, panthenol), peptides, hydroxyl acids, sugar amines, ceramides, and metals were specifically examined.
Conclusions:
- Several cosmeceutical agents, including specific vitamins, peptides, and ceramides, demonstrate efficacy in improving skin appearance based on clinical data.
- The review emphasizes the importance of evidence-based ingredients in cosmetic formulations.
- Further research into the mechanisms and synergistic effects of these agents may enhance cosmetic product development.
Related Concept Videos
01:26Pharmaceutical Equivalents
As defined by regulatory standards, pharmaceutical equivalents require generic drug products to have identical dosage forms and chemically identical active pharmaceutical ingredients (APIs). They must adhere to compendial or applicable standards for potency, content uniformity, disintegration times, and dissolution rates. In the case of modified-release dosage forms, variations in drug content are permissible as long as the delivered amount remains consistent with the innovator drug product.
01:19Clinical Applications of Epidermal Stem Cells
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
01:27The Skin Microbiota
The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
01:12Renewal of Skin Epidermal Stem Cells
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
01:28Drug Products: Biologics, Biosimilars and Interchangeables
Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...
01:16Confocal Fluorescence Microscopy
Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...