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Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats
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Tourettism in multiple sclerosis: a case report.

V Nociti1, A Fasano, A R Bentivoglio

  • 1Department of Neuroscience, Institute of Neurology, Catholic University, Rome, Italy.

Journal of the Neurological Sciences
|August 22, 2009
PubMed
Summary
This summary is machine-generated.

Tourettism, or Tourette Syndrome-like symptoms, can rarely occur in Multiple Sclerosis (MS) patients. This study suggests a potential causal link between MS progression and the development of these tics.

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Area of Science:

  • Neurology
  • Neuropsychiatry

Background:

  • Tourettism encompasses Tourette Syndrome (TS)-like symptoms secondary to neurological disorders or drug exposure.
  • The co-occurrence of Tourettism and Multiple Sclerosis (MS) is exceptionally rare, with only two prior case reports.

Observation:

  • A 30-year-old woman with secondary-progressive MS developed TS-like symptoms seven years post-diagnosis.
  • Her brain MRI revealed increased lesion burden and atrophy around Sylvian fissures.
  • The patient's tics showed responsiveness to quetiapine treatment.

Findings:

  • Progressive MS-related brain atrophy and white matter changes may underlie tic development.
  • Atrophy in specific brain regions and impaired cortico-striato-thalamo-cortical circuits are implicated.
  • The observed Tourettism in this MS patient is hypothesized to be causally related, not coincidental.

Implications:

  • This case expands the understanding of rare neurological associations in MS.
  • It highlights the potential for MS progression to trigger secondary Tourettism.
  • Further research is warranted to explore the pathophysiological mechanisms linking MS and Tourettism.