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[GIST: adjuvant treatment in Austria]

Thomas Brodowicz1, Thomas Kühr

  • 1Klinische Abteilung für Onkologie, Universitätsklinik für Innere Medizin I, Medizinische Universität Wien-AKH, Wien, Austria. thomas.brodowicz@meduniwien.ac.at

Wiener Medizinische Wochenschrift (1946)
|August 22, 2009
PubMed

Adjuvant treatment of gastrointestinal stromal tumor (GIST) patients with Imatinib (400 mg/d) is associated with a statistically significant improvement of relapse-free survival. Risk of relapse has been determined according to Fletcher [8] in the majority of the mentioned trials. However, classification according to Miettinen [9] and Joensuu [10] plus consideration of mutational status might be more accurate. Based upon currently available data, the Austrian GIST-Panel recommends adjuvant treatment with 400 mg Imatinib/day for 1 year for KIT positive GIST patients with a high or moderate risk of relapse (according to Joensuu) [10] following complete resection of the primary tumor.

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