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Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation
Published on: July 23, 2012
[The expression pattern and possible function of microRNA-34a in neurons]
Yan Ting Qi1, Yu Zhao, Zhi Zhang
1Institute of Molecular and Chemical Biology, East China Normal University, Shanghai 200062, China.
Fen Zi Xi Bao Sheng Wu Xue Bao = Journal of Molecular Cell Biology
|August 25, 2009
Abstract:
Using Northern blotting, ISH and FISH, we demonstrated miR-34a expresses with aging in the brain of rhesus monkey and rat. Correspondingly, the same trend was found in the primary cultures of cortical neurons. Moreover, we found that induction of miR-34a led to neuronal apoptosis by targeting BCL-2. Our study suggests that miR-34a may play critical roles in neuronal development and ageing.
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