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Related Concept Videos

Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
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Icariin: a potential osteoinductive compound for bone tissue engineering.

Jiyuan Zhao1, Shinsuke Ohba, Yusuke Komiyama

  • 1Department of Chemistry and Biotechnology, School of Engineering, University of Tokyo, Tokyo, Japan.

Tissue Engineering. Part A
|August 25, 2009
PubMed
Summary
This summary is machine-generated.

Icariin, a compound from Epimedium pubescens, effectively promotes bone formation. This natural compound shows promise for bone regenerative medicine and tissue engineering applications.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Pharmacology

Background:

  • Bone diseases require novel treatments with safe, affordable, and potent bone-forming drugs.
  • Current bone regenerative medicine strategies need effective osteogenic compounds.

Purpose of the Study:

  • To investigate the osteogenic effects of icariin, a natural compound from Epimedium pubescens.
  • To evaluate icariin's potential in bone regenerative medicine and tissue engineering.

Main Methods:

  • Assessed icariin's effect on osteogenic differentiation in preosteoblastic and MC3T3-E1 cells.
  • Investigated synergistic effects with other compounds and enhancement of bone morphogenetic protein-2.
  • Evaluated in vivo bone formation using a mouse calvarial defect model and senescence models.

Main Results:

  • Icariin induced osteogenic differentiation and mineralization in vitro.
  • Icariin synergistically enhanced osteogenic differentiation with other compounds and BMP-2.
  • Significant new bone formation and vascularization were observed in vivo in the icariin-treated mouse model.

Conclusions:

  • Icariin demonstrates potent osteogenic effects both in vitro and in vivo.
  • Icariin is a promising candidate for bone regenerative medicine and bone tissue engineering.
  • The findings support icariin's potential as a safe and effective therapeutic agent for bone diseases.