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Related Experiment Video

Updated: Jun 20, 2026

Transmitochondrial Cybrid Generation Using Cancer Cell Lines

Transmitochondrial Cybrid Generation Using Cancer Cell Lines

Published on: March 17, 2023

Mitochondrial gateways to cancer.

Lorenzo Galluzzi¹, Eugenia Morselli, Oliver Kepp

¹INSERM, U848, Institut Gustave Roussy, PR1, 39 Rue Camille Desmoulins, F-94805 Villejuif, France.

Molecular Aspects of Medicine

|August 25, 2009

Summary

Mitochondria, vital for cell life, also trigger cell death and are implicated in cancer. Deregulated mitochondrial functions contribute to tumor development and progression.

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Transmitochondrial Cybrid Generation Using Cancer Cell Lines

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MitoCeption: Transferring Isolated Human MSC Mitochondria to Glioblastoma Stem Cells

MitoCeption: Transferring Isolated Human MSC Mitochondria to Glioblastoma Stem Cells

Published on: February 22, 2017

Area of Science:

Cell Biology
Biochemistry
Oncology

Background:

Mitochondria are crucial for cellular survival, ATP generation, and biosynthesis.
They also play a role in programmed cell death, particularly apoptosis.
Mitochondrial dysfunction is frequently observed in cancer cells.

Purpose of the Study:

To review the mechanisms by which mitochondria contribute to cancer development and progression.
To highlight the link between mitochondrial functions and the hallmarks of cancer.

Main Methods:

Literature review of mitochondrial roles in cellular processes and cancer.
Analysis of how mitochondrial deregulation impacts cancer hallmarks and tumor features.

Main Results:

Mitochondria are involved in ATP production, reactive oxygen species generation, and anabolic pathways.
Mitochondrial dysfunction is linked to limitless replication, evasion of apoptosis, and enhanced metabolism in cancer.
Mitochondria integrate signals controlling cell survival and death pathways.

Conclusions:

Mitochondria are central to both normal cellular functions and the development of cancer.
Targeting mitochondrial pathways may offer therapeutic strategies for cancer treatment.