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Updated: Jun 20, 2026
Tissue Preparation and Immunostaining of Mouse Craniofacial Tissues and Undecalcified Bone
Published on: May 10, 2019
Expression of Twist in different subtype of ameloblastomas
Yang Feng1, Yin-Mei Zhou, Cheng-Ge Hua
1State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Sichuan, People's Republic of China.
Objective:
The objective of this study was to investigate the pattern of Twist expression in a series of ameloblastomas, and to study the possible role of Twist in the bone destruction and local invasiveness of ameloblastoma variants.
Study Design:
Immunohistochemical study was performed for Twist protein in 53 ameloblastomas (32 solid/multicystic [SA] and 21 unicystic [UA]).
Results:
The salient finding was that expression of Twist was related to the histological subtype of tumors, as there was a higher expression in SA (14/32, 43.75%) as compared to UA (4/21, 19.05%) (P < .05). Both nuclei and cytoplasm positivities were detected in positive cases, whereas cytoplasmic staining was diffused and predominant. Cases rich in stromal cells showed a higher percentage of positive cells than those with less stroma.
Conclusions:
Our results suggest that Twist expression might be associated with invasion in ameloblastoma variants, and stromal cells might play a regulatory role during tumor development.
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