Related Experiment Video
Updated: Jun 20, 2026
07:32
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Development of multiple-layer polymeric particles for targeted and controlled drug delivery
Bhanuprasanth Koppolu1, Maham Rahimi, Sivaniarvindpriya Nattama
1Biomedical Engineering Program, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.
Nanomedicine : Nanotechnology, Biology, and Medicine
|August 25, 2009
Summary
Researchers developed multilayered magnetic particles using poly(N-isopropylacrylamide) (PNIPAAm) and poly(D,L-lactide-co-glycolide) (PLGA) for controlled drug delivery. These particles enable targeted delivery of multiple drugs with distinct release profiles.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Development of advanced drug delivery systems is crucial for targeted and controlled therapeutic interventions.
- Multilayered nanoparticles offer potential for encapsulating multiple therapeutic agents with varied release kinetics.
Purpose of the Study:
- To synthesize and characterize multilayered magnetic particles for targeted and controlled drug delivery.
- To investigate the influence of formulation parameters on particle characteristics.
- To evaluate the drug release profiles of encapsulated model drugs.
Main Methods:
- Synthesis of multilayered magnetic nanoparticles with a magnetic core and poly(N-isopropylacrylamide) (PNIPAAm) and poly(D,L-lactide-co-glycolide) (PLGA) shells.
- Characterization using transmission electron microscopy (TEM) and factorial analysis.
- In vitro drug release studies using bovine serum albumin (BSA) and curcumin.
Main Results:
- Successful synthesis of multilayered particles with embedded magnetic nanoparticles confirmed by TEM.
- Particle size influenced by surfactant concentration, sonication power, and PLGA concentration.
- Demonstrated biphasic drug release (initial burst and sustained release) for BSA and curcumin.
- BSA release was temperature-dependent.
Conclusions:
- Multilayered magnetic particles composed of PNIPAAm and PLGA are feasible for drug delivery.
- These particles can encapsulate and release multiple drugs with different mechanisms.
- The developed system holds promise for targeted and controlled delivery of therapeutics.
Related Concept Videos
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
01:24Modified-Release Drug Delivery Systems: Site-Targeted
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
01:19Modified-Release Drug Delivery Systems: Rate-Programmed II
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
01:23Modified-Release Drug Delivery Systems: Classification
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
01:22Modified-Release Drug Delivery Systems: Rate-Programmed I
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
01:11Oral Drug Delivery Systems: Delayed-Release Systems
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...