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Factors Influencing Drug Absorption: Disease States and Pharmacology01:25

Factors Influencing Drug Absorption: Disease States and Pharmacology

Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents01:20

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Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
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Development of Human Microbiota01:30

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The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
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Ginger Moxibustion, A Non-pharmacological Treatment, for Diarrhea in Patients with Chronic Obstructive Pulmonary Disease
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Diarrhea and malabsorption in the elderly.

Lawrence R Schiller1

  • 1Digestive Health Associates of Texas, 712 North Washington Avenue, #200, Dallas, TX 75246, USA. lrsmd@aol.com

Gastroenterology Clinics of North America
|August 25, 2009
PubMed
Summary
This summary is machine-generated.

Diarrheal disorders affect many people annually. This review focuses on the significant impact of diarrhea on fluid and nutritional balance in the elderly, a vulnerable population.

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Published on: November 27, 2016

Area of Science:

  • Gastroenterology
  • Geriatrics
  • Internal Medicine

Background:

  • Diarrheal disorders are highly prevalent across all age groups.
  • Acute diarrhea affects 5-7% of the population yearly, while chronic diarrhea impacts 3-5% for over 4 weeks.
  • Prevalence is presumed similar in older adults, necessitating specific attention.

Purpose of the Study:

  • To review the impact of diarrhea in the elderly population.
  • To highlight physiological vulnerabilities in older individuals regarding diarrhea's effects.
  • To discuss implications for fluid and nutritional balance in geriatric patients.

Main Methods:

  • Literature review of studies on diarrhea in the elderly.
  • Analysis of physiological challenges faced by older adults with diarrhea.
  • Synthesis of information on fluid and nutritional balance disruptions.

Main Results:

  • Elderly individuals are physiologically less resilient to diarrhea.
  • Diarrhea can severely disrupt fluid balance in older adults.
  • Nutritional balance is also significantly compromised in this demographic.

Conclusions:

  • Diarrhea poses a substantial health risk to the elderly.
  • Specialized management strategies are crucial for geriatric patients experiencing diarrhea.
  • Maintaining fluid and nutritional status is paramount in treating elderly patients with diarrhea.